Courtesy of renalandurologynews.com
Low levels of total and bioavailable testosterone may be associated with an increased risk of dementia in elderly men, according to French investigators.
From a cohort of 3,650 men aged 65 years and older, Laure Carcaillon,
MD, of Inserm in Villejuif, France, and collaborators compared 105 men
with incident dementia and a random sample of 413 men without dementia.
The median follow-up period was 3.1 years.
Compared with the middle
tertile of total testosterone (total-T) level, the lower and upper
tertiles were associated with a 2.3 times and 1.9 times increased risk
of dementia, respectively.
Low bioavailable testosterone (bio-T) also
was associated with a greater risk for dementia, especially among men
aged 80 years and older, investigators reported online ahead of print in
Alzheimer's & Dementia.
In men aged 80 and older, low bio-T
was associated with a significant threefold increased risk of dementia;
in men younger than 80, it was associated with a nonsignificant 7%
increased risk.
Additionally, the risk of dementia associated with low bio-T was
greater in men with a high level of education compared with men who had a
low level of education.
Taken together, the authors noted, their results support the
hypothesis of a deleterious effect of low testosterone concentrations on
brain aging, and also suggest that high levels of total-T could
increase this risk.
Andropause: Sometimes called "male menopause," it's the Male Hormone Crisis men don't talk about. Surprisingly, women often need it too. We'll talk about testosterone replacement ( TRT ) therapy here, discussing the topic that affects men and women - Published Monday through Friday, from the upcoming book by author Kenneth E. Lamb, "Andropause: A Man's Fate, A Woman's Fear." (C) 2013
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